Cardiac Pathophysiology: Electrophysiology and Heart Valves

Session Chair(s)

• 

  Hoda Hatoum, PhD (she/her/hers)

  Assistant Professor
  Michigan Technological University, Michigan, United States
• 

  Sung Jin Park, PhD (he/him/his)

  Assistant Professor
  Georgia Tech and Emory Univ
  Atlanta, Georgia, United States

Track Chair(s)

• 

  Feng Zhao, PhD (she/her/hers)

  Professor of Biomedical Engineering
  Texas A & M University, United States
• 

  Esak Lee, PhD (he/him/his)

  Assistant Professor
  Cornell University
  Ithaca, New York, United States

Presentations:

• 3:45 PM – 4:15 PM EST

  Bicuspid Aortic Valve-Associated Aortic Pathophysiology: A Multilayer Problem of Oxidative Stress, Matrix Architecture, Biomechanics, and Microvascular Function
  

  Invited Speaker: Julie Phillippi, PhD (she/her/hers) – University of Pittsburgh
• 4:15 PM – 4:30 PM EST

  A Co-culture Model to Study Cellular Crosstalk in Aortic Valve Stenosis Sexual Dimorphism
  

  Presenting Author: Alex Khang, PhD (he/him/his) – University of Colorado Boulder

  Co-Author: Abigail Barmore – University of Colorado Boulder

  Co-Author: Nicole E. Friend, PhD (she/her/hers) – University of Colorado Boulder

  Co-Author: Gabriel Wu – University of Colorado Boulder

  Last Author: Kristi S. Anseth – University of Colorado Boulder
• 4:30 PM – 4:45 PM EST

  Trimethylamine Oxide (TMAO), a gut metabolite, activates quiescent valvular interstitial cells through the PERK pathway
  

  Presenting Author: Ana Maria Porras, PhD – University of Florida

  Co-Author: Samanvitha Deepthi Sudi (she/her/hers) – University of Florida

  Co-Author: Tanmayee Kolli (she/her/hers) – University of Florida
• 4:45 PM – 5:00 PM EST

  Patient-specific long-term prediction of mitral valve transcatheter edge-to-edge repair
  

  Presenting Author: Natalie Simonian, MSE – University of Texas at Austin

  Co-Author: Sneha Vakamudi, MD – Ascension Texas Cardiovascular

  Co-Author: Mark Pirwitz – Ascension Texas Cardiovascular

  Last Author: Michael S. Sacks, PhD (he/him/his) – University of Texas at Austin
• 5:00 PM – 5:15 PM EST

  Pretreatment of Bioprosthetic Heart Valve Leaflets with Pyridoxamine (Vitamin B6) Enhances Endothelial Cell Adhesion and Viability
  

  Presenting Author: Tina E. Thomas, MSE – University of Pennsylvania

  Co-Author: Stanley Stachelek, PhD – Children's Hospital of Philadelphia/ University of PennsylvaniaDr. Stachelek's laboratory focuses largely on the anti-inflammatory properties of the transmembrane protein CD47, and its cognate receptor Signal Regulatory Protein alpha (SIRPa). SIRPa is a Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) expressing protein. ITIMs are a family of protein receptors that function to limit or terminate an immune response. The ultimate goal of Dr. Stachelek's research is to target these receptors to reduce the host inflammatory response that is observed to reduce the efficacy of such cardiovascular devices as stents, bioprosthetic heart valves, and pacemakers.

  Primary Investigator: Robert Levy, MD – Children's Hospital of Philadelphia/ University of Pennsylvania