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Michael Buckenmeyer, PhD

CRTA Postdoctoral Fellow
National Cancer Institute
Frederick, Maryland, United States

Michael is an innovative bioengineer with 10+ years of experience applying tissue engineering principles and biomaterials-based approaches to address unmet clinical needs. He received a BS in Mechanical Engineering from Fairfield University in 2011, where he learned about the fundamentals of engineering and was first introduced to the field of tissue engineering. He completed his MS in Biomedical Engineering from Syracuse University in 2014. For his Master's thesis, he initiated a collaborative independent study at the Diabetes Research Institute in Miami, FL where he developed methods for isolating RNA from pancreatic islets from healthy and diabetic patients for transcriptome analysis. He continued his graduate studies at the University of Pittsburgh's McGowan Institute for Regenerative Medicine, where he received his PhD in Bioengineering in 2020. His dissertation focused on the development of new methods for restoring fertility in cancer patients post-chemotherapy. He established an ovarian-specific extracellular matrix (ECM) hydrogel to facilitate the delivery and engraftment of ovarian follicles in situ. His approach gave rise to multiple healthy litters demonstrating a potential non-invasive platform for naturally restoring fertility. Currently, Michael is in his 4th year as a CRTA postdoctoral fellow at the National Cancer Institute. He has pioneered the development of a novel 3D in vitro tumor spheroid model to probe cancer cell responses in distinct tumor microenvironments (TME) – with tunable ECM composition. Their team has shown promising results for improving in vitro tumor model fidelity and correlation with in vivo tumor phenotypes.

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