Children's Hospital of Philadelphia/ University of PennsylvaniaDr. Stachelek's laboratory focuses largely on the anti-inflammatory properties of the transmembrane protein CD47, and its cognate receptor Signal Regulatory Protein alpha (SIRPa). SIRPa is a Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) expressing protein. ITIMs are a family of protein receptors that function to limit or terminate an immune response. The ultimate goal of Dr. Stachelek's research is to target these receptors to reduce the host inflammatory response that is observed to reduce the efficacy of such cardiovascular devices as stents, bioprosthetic heart valves, and pacemakers., United States
Dr. Stachelek's laboratory focuses largely on the anti-inflammatory properties of the transmembrane protein CD47, and its cognate receptor Signal Regulatory Protein alpha (SIRPa). SIRPa is a Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) expressing protein. ITIMs are a family of protein receptors that function to limit or terminate an immune response.
The ultimate goal of Dr. Stachelek's research is to target these receptors to reduce the host inflammatory response that is observed to reduce the efficacy of such cardiovascular devices as stents, bioprosthetic heart valves, and pacemakers.
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Thursday, October 24, 2024
5:00 PM - 5:15 PM EST