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Tanmoy Saha, PhD (he/him/his)

Instructor (Associate Bioengineer)
Brigham and Women's Hoapital, Harvard Medical School
Cambridge, Massachusetts, United States

I am an Instructor at Harvard Medical School and associate bioengineer at Brigham and Women’s Hospital. My research focuses on immunoengineering and cellular communication. My overarching research goal is to use chemical and bioengineering tools to understand different cellular mechanisms of cancer and design, develop, and deploy novel therapeutic agents. I investigated the novel immune evasion mechanism of cancer cells by nanotube-mediated mitochondria hijacking from immune cells. Currently, I am developing novel drugs to block such mechanisms. Additionally, I am interested in immunoengineered therapeutics, where I use chemical conjugation between antibodies and drug/nanoparticles to design bispecific therapeutics. One of my works related to bispecific antibody-conjugated drug-loaded nanoparticles has shown increased efficacy in lung cancer by activating innate and adaptive immunity. During my, PhD training I introduced the first-ever example of artificial ion channels inducing apoptosis in cancer cells by disrupting mitochondrial homeostasis.

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