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Xuefeng Wang, PhD

Associate Professor
Hoxworth Center, United States

Dr. Xuefeng Wang is an associate professor in the research division of Hoxworth center, college of medicine at University of Cincinnati. Prior to joining UC in 2023, he held a position of associate professor of biophysics at Iowa State University, where he received tenure in 2019.

Dr. Wang obtained B.S. and M.S. of Physics from Tsinghua University in China, and Ph.D. of Physics from Purdue University in 2009. He worked as a postdoctoral researcher at University of Illinois at Urbana-Champaign in 2010-2015, where he was trained as a biophysicist and gained specialty in single molecule imaging and cell mechanobiology.

Dr. Wang is dedicated to biomedical studies with innovative biophysical and biochemical approaches, a research principle that he has followed throughout his academic career. Dr. Wang and his lab have published 45 research articles. Some notable achievements include: Pioneered constructing DNA as molecular tension sensors to study cell mechanobiology (Science, 340, 991-994, 2013). Calibrated integrin molecular tension and Notch receptor tension for the first time (Science, 340, 991-994, 2013). Revealed adhesive force maps in platelets for the first time (Biosensors and Bioelectronics, 100, 192-200, 2018). Developed the first super-resolution force microscopy based on single molecular tension imaging and localization (JACS, 142, 15, 6930-6934, 2020). Discovered rich membrane-bound DNase activity in podosomes in macrophages (Journal of Cell Biology, 220, 7, 2021). Imaged integrin tensions in podosomes in macrophages at the sub-micron scales (ACS Nano, 16, 2022).

In 2023, with the expanding research interest in blood cells and immune cells, Wang lab joined the Hoxworth Blood Center. The center provides steadfast research support to the Wang Lab, facilitates the access to invaluable biological samples, and fosters seamless interdisciplinary collaborations. A research team with diverse expertise is being brought together in Wang lab to continue the exciting research in the field of cell mechanobiology and enzymology, with an emphasis on the blood cells including platelets, macrophages, neutrophils, and various other immune cells.

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